Please note that this version of the REACH directive is out of date.
Go to new version now
very toxic
ARTICLE-23: Specific provisions for phase-in substances [go to this ARTICLE]
... (b) phase-in substances classified as very toxic to aquatic organisms which may cause long-term adverse effects in the aquatic environment (R50/53) in accordance with Directive
67/548/EEC, and manufactured in the Community or imported in quantities reaching 100 tonnes or more per year per manufacturer
or per importer, at least once after 1 June 2007; ...
ARTICLE-VII: STANDARD INFORMATION REQUIREMENTS FOR SUBSTANCES MANUFACTURED OR IMPORTED IN QUANTITIES OF ONE TONNE OR MORE [64] [go to this ARTICLE]
... 8.1.Skin irritation or skin corrosionThe assessment of this endpoint shall comprise the following consecutive steps:(1)an
assessment of the available human and animal data,(2)an assessment of the acid or alkaline reserve,(3)in vitro study for skin corrosion,(4)in vitro study for skin irritation. | 8.1.Steps 3 and 4 do not need to be conducted if:the available information indicates that the criteria
are met for classification as corrosive to the skin or irritating to eyes, orthe substance is flammable in air at room temperature,
orthe substance is classified as very toxic in contact with skin, oran acute toxicity study by the dermal route does not indicate skin irritation up to the limit dose level (2000 mg/kg body weight). | ...
ARTICLE-VIII: STANDARD INFORMATION REQUIREMENTS FOR SUBSTANCES MANUFACTURED OR IMPORTED IN QUANTITIES OF 10 TONNES OR MORE [66] [go to this ARTICLE]
... 8.1.1.In vivo skin irritation | 8.1.1.The study does not need to be conducted if:the substance is classified as corrosive to the skin or as a skin irritant, orthe substance
is a strong acid (pH ≤ 2,0) or base (pH ≥ 11,5), orthe substance is flammable in air at room temperature, orthe substance
is classified as very toxic in contact with skin, oran acute toxicity study by the dermal route does not indicate skin irritation up to the limit dose level (2000 mg/kg body weight). | ...
ARTICLE-XVII: RESTRICTIONS ON THE MANUFACTURE, PLACING ON THE MARKET AND USE OF CERTAIN DANGEROUS SUBSTANCES, PREPARATIONS AND ARTICLES
[go to this ARTICLE]
... Substances with specific effects on human health (see chapter 4 of Annex VI of Directive 67/548/EEC) that are classified as carcinogenic,
mutagenic and/or toxic for reproduction in categories 1 or 2 are ascribed Note E if they are also classified as very toxic (T+), toxic (T) or harmful (Xn). For these substances, the risk phrases R20, R21, R22, R23, R24, R25, R26, R27, R28, R39, R68 (harmful), R48 and R65 and all combinations of these
risk phrases shall be preceded by the word "Also". ...